Ngabe usebenza emkhakheni wocwaningo lwe-biomedical? Uma kunjalo, kungenzeka ukuthi uke wezwa ngeSulfo-NHS. Njengoba indima ebalulekile yale nhlanganisela ocwaningweni iyaqhubeka nokuqashelwa, le mpikiswano ingena kwamalentshi amaningi emhlabeni jikelele. Kulesi sihloko, sixoxa ngokuthi yimiphi iSulfo-NHS nokuthi kungani iyithuluzi elibalulekile kulabo abafunda isayensi yemvelo.
Okokuqala, yini i-sulfo-NHS? Igama limi kancane, ngakho-ke ake sikwephule. I-Sulfo imele i-sulfonic acid kanye ne-NHS imele i-N-Hydroxysuccimide. Lapho lezi zinhlanganisela ezimbili zihlangana,Sulfo-nhskukhiqizwa. Le mpikiswano inokusetshenziswa okuningana ocwaningweni lwe-biomedical, kepha enye yezindawo ezibalulekile yikhono lokukhetha ama-proteins.
I-Sulfo-NHS isebenza ngokuphendula ngama-Andines (ie -NH2 Amaqembu) emaketangeni aseceleni asele ezinsalweni ze-lysine kumaprotheni. Empeleni, amaprotheni we-sulfo-NHS "amaprotheni athi" abenze kube lula ukubona futhi ahlaziye ezinhlotsheni ezahlukahlukene. Lokhu kuholele ezindaweni eziningi zocwaningo okwazi ukuqhubekela phambili ngokunemba okukhulu kanye namazinga aphezulu wemininingwane.
Ngakho-ke, yini i-sulfo-NHS esetshenziselwa yona? Ukusetshenziswa okukodwa okuvamile kwale compact kucwaninga nge-immunology. I-Sulfo-NHS ikhonjiswe ukulebula ngempumelelo ama-antibodies nama-antigen, evula izindlela ezintsha zocwaningo lokuphazamiseka kwamasosha omzimba nezifo. Ngokwengeziwe,Sulfo-nhsIngasetshenziswa ezifundweni ze-protein-protein protein njengoba ivumela abacwaningi ukuthi basheshe babone lapho amaprotheni amabili ehlangana.
Enye indawo lapho kusetshenziswa khona i-sulfo-NHS ebanzi yilokho kwama-proteemics. Ama-protemics afunda ukwakheka kanye nomsebenzi wawo wonke amaprotheni emzimbeni, futhiSulfo-nhsiyithuluzi elibalulekile kulokhu kuhlaziywa. Ngokumaka amaprotheni nge-sulfo-NHS, abacwaningi bangenza izivivinyo zokuthola imininingwane eningiliziwe mayelana ne-proteome yomzimba enikeziwe, engasiza ekuboneni ama-biomarkers angaba khona wezifo.
I-Sulfo-NHS nayo idlala indima ekwakhiweni kwemithi emisha. Lapho abacwaningi bezama ukuthuthukisa umuthi omusha, kubalulekile ukuqiniseka ukuthi kuhlose amaprotheni ahlosiwe hhayi amanye amaprotheni emzimbeni. NgokusebenzisaSulfo-nhsUkukhetha amaprotheni okukhetha, abacwaningi bangakhomba imigomo eqondile yezidakamizwa ezingaba khona, ezingasiza ukusheshisa inqubo yokuthuthukiswa kwezidakamizwa.
Ngakho-ke lapho unayo! I-Sulfo-NHS kungenzeka ingabi yithemu eyaziwa kahle ngaphandle komphakathi wesayensi, kepha le mpikiswano ishesha ukuba yithuluzi elibalulekile ocwaningweni lwe-biomedical. Kusuka ekucwaningweni kwe-immunology kuma-proteomics ekuthuthukisweni kwezidakamizwa, ama-sulfo-NHS kusiza abaphenyi benze intuthuko enkulu kulezi zindawo futhi siyajabula ukubona ukuthi yikuphi okutholakele okulandelayo.
Isikhathi sePosi: Jun-12-2023