Ama-alkynes akhona kakhulu emikhiqizweni yemvelo, ama-molecule asebenzayo we-biologically kanye nezinto zokusebenza eziphilayo.Ngasikhathi sinye, zingabaxhumanisi ezibalulekile ku-organic synthesis futhi zingabhekana nokusabela okuchichimayo kokuguqulwa kwamakhemikhali.Ngakho-ke, ukuthuthukiswa kwezindlela ezilula nezisebenzayo zokwakha ama-alkynes kuphuthuma kakhulu futhi kuyadingeka.Nakuba ukusabela kwe-Sonogashira okucutshungulwa yizinsimbi ezishintshayo kungenye yezindlela eziphumelela kakhulu nezilula zokuhlanganisa i-aryl noma i-alkenyl esikhundleni se-alkynes, ukusabela kokuhlanganisa okubandakanya ama-alkyl electrophiles angacushiwe kungenxa yokusabela okuseceleni okufana nokuqedwa kwe-bH.Kusagcwele izinselele nocwaningo oluncane, ikakhulukazi kukhawulelwe kuma-alkane angenabungane emvelo futhi abizayo.Ngakho-ke, ukuhlola nokuthuthukiswa kokusabela kwe-Sonogashira kwama-reagents amasha, angabizi futhi atholakala kalula e-alkylation kuzoba ngokubaluleka okukhulu kokubili ekuhlanganiseni kwelabhorethri kanye nezicelo zezimboni.Ithimba laklama ngobuhlakani futhi lathuthukisa i-amide-type NN2 pincer ligand entsha, etholakala kalula futhi ezinzile, okwathi ngokokuqala ngqa yaqaphela ukukhethwa okuphumelelayo nokuphezulu kokuphuma kwe-alkylamine nama-alkynes abulalayo anezinhlobonhlobo zemithombo ye-nickel catalytic, eshibhile futhi kulula ukuyenza. thola.Ukusabela okuhlanganayo kusetshenziswe ngempumelelo ekuguqulweni kwe-deamination sekwephuzile kanye nokuguqulwa kwe-alkynylation kwemikhiqizo yemvelo eyinkimbinkimbi nama-molecule ezidakamizwa, okugqamisa ukusebenza kahle kokusabela nokuhambisana kweqembu elisebenzayo, futhi inikeza ubusha bokuhlanganiswa kwama-alkyl abalulekile afakwe esikhundleni se-alkyl.Nezindlela ezisebenzayo.
Isikhathi sokuthumela: Nov-22-2021